... the further you get from standard, the more likely players are to make betting mistakes. These are art, but they are also tools to be used.
Agreed... I would just add that your own particular roster of players may be the biggest factor in whether your game can handle unusual color schemes.
If you have a private game consisting entirely of regulars, then any initial confusion about colors/denoms should wear off within 1-2 sessions. Once people get used to it, the value of the chips will become second nature. (This is the main thesis behind my
EXTREMELY POPULAR 
argument against denoms.)
But if you are hosting a more public, or one where for some other reason the cast of characters changes a lot, then some new faces are going to have to climb that learning curve every session. (That might be an angle for the few regs...)
I’d also think about whether these guys/gals play a lot in casinos or other private games. If they are regs in either East or West Coast casinos, then certain colors are going to mean a lot more to them.
By the same token (no pun intended), I’ve been to some low-stakes home games where more than half the players pretty much *only* play in that one house... I played for years with a couple of guys who had
never set foot in a casino. Not once. And they didn’t play in other home games, just the one. All they knew was the color scheme from that one home game. So they would probably freak out at first if the colors changed, but then would get used to it, and not confuse the colors with other games.
For me, finding unusual colored denoms in a game would be fun, especially if they were quality chips... But it would take some getting used to if, say, the reds were 25s, the whites were 5s, and the greens were 1s. If a New York venue did that, I’d assume they were either messing with people or just had no clue.