This is purely a matter of preference / aesthetics, but I would never want to run it twice (or more). Running it twice is a way to reduce variance, to simultaneously minimize both your losses and gains. IMHO that's all part of bankroll management, and you should do your bankroll management away from the table. Once you're sitting, you should (again, this is a matter of preference) revel in the huge swings inherent in the game. Are you there to scrape out your +2bb/100 hands or are you there to play poker ?
This sounds gambley, and fishy, and exploitable, but the point is that it's not. Running it once or twice or ten times doesn't change you from a thoughtful, practiced, competent player into a sucker or vice versa. It's only a matter of variance, and variance can (and should be) managed away from the table but indulged at the table.
If nothing else, being fake-gambley at the table will encourage the other players to be gambley as well, in ways that do effect their EV, in your favor.