Would you? Is it just because they're available? I have a small set - almost 400 chips. I've never actually played a real nickel game; I've just used these for playing with my kids. But my sense is, if and when I actually put these into play in a real cash game, I wouldn't put the 50 centers into play at the same time as the quarters and dollars, unless I ran out of chips.and then some 50c