I've stayed downtown and on strip multiple times. I will continue to switch between the two, depending on the trip.
Downtown Pros:
Everything is cheaper downtown. Cheap rooms can be found on the strip, but resort fees run near $30 a night. It's also easy walking distance from the 2 furthest points (Plaza to El Cortez). So any hotel in that area is walking distance to the Golden Nugget, as it is fairly central. Outside of the downtown area, but within walking distance are some of the best restaurants in Vegas for a reasonable price. Walking from Point A to Point B on Freemont street is comfortable in June as it's covered and air conditioned. On the strip, it is stupid hot (but a dry heat, so you wont get all sweaty). During the WSOP, the Golden Nugget has it's own championship poker series, which fills at least 2 ballrooms. It draws a lot of players, and it keeps the cash games super active (but the wait can also be long)
Also, this is the scenery downtown...
Sure, they may have only had one eye - I don't know. I didn't look that high.
Downtown Cons:
Strip Vegas is Vegas. It's what you see on TV. It's the big resort hotels. There is more to see and do. If it's your first trip, or you want to catch a show, that's where it's all at. Bellagio, Caesars, Aria. It's all on the strip. The WSOP puts out a discount code when the WSOP draws close. You are supposed to play in the WSOP, but nobody has ever asked for proof, and there have been a couple of trips where I went and haven't played. It's the best deal you will likely get, unless you stay in a less pretty area.
Downtown is a well patrolled, very "safe" area, but if you leave the light, all bets are off. I grew up in Detroit, and have no fear of crime. In fact, the most pleasant people I have ever come across in Vegas looked to be thugs. Mind your buisness, they mind theirs. In the daytime, Mrs Zombie and I walked quite a distance from the "safety" of Fremont. In the day, it's just as safe as any American city. At night though... stay in the light.
I strongly recommend my trip reports, as I cover everything, not just poker, when I'm in Vegas.
2017
2016
2015