I've used acrylic carriers for over a decade with no problems. That said, It's a careful carry to the car and then to my office (where I play). I do double check the screws in the bottom regularly, and the cages I use have the larger "paddle" across the bottom that use three screws.
I've considered epoxying the paddle to the bottom, but again, haven't had a problem nor felt it would be. I don't manhandle the cages and don't try to do anything crazy while carrying them.
I took three full 1000 count cages to RIA-I last October, a full two hour drive each way, and hauling them was not a problem, nor was I ever concerned with them.
That said, I did get a 1000 chip Versa carrier a few months ago:
https://www.amazon.com/Versa-Games-1000pc-Deluxe-Carrier/dp/B07L8LLCR8
and have liked it a lot as it's much more secure, lathes shut with six latches and feels a lot more robust.
There is a bit of a trick trying to get the bottom racks out of the case. There are posts about the rack tipping trick to get the bottom ones out, but I have been using a sling made of an old scrap of speed cloth that makes that process unnecessary and makes getting chips out of the bottom much easier. I need to make a post on how this works.